Effect of allogeneic hematopoietic cell transplantation in first complete remission on post-relapse complete remission rate and survival in acute myeloid leukemia
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چکیده
منابع مشابه
Effect of allogeneic hematopoietic cell transplantation in first complete remission on post-relapse complete remission rate and survival in acute myeloid leukemia.
Several studies have shown that allogeneic hematopoietic cell transplantation (HCT) in first complete remission (CR1) of AML reduces the risk of relapse and improves relapse-free survival in intermediateand poor-risk AML. Benefits in (overall) survival are less obvious. One possible explanation is that following the occurrence of relapse, previous receipt of allogeneic HCT in CR1 is associated ...
متن کاملfirst complete remission versus other- than- first complete remission in acute myelogenous leukemia with allogeneic hematopoietic stem cell transplantation
introduction: the traditional goal of the treatment of acute myelogenous leukemia is to produce and maintain a complete remission (cr).the difference in survival time was entirely attributable to the duration of time spent in cr .in this study, the outcome of aml patients with allogeneic hsct in cr1 versus other than cr1 was compared. patients and methods: since march 1991 until november 2008, ...
متن کاملAllogeneic hematopoietic cell transplantation for acute myeloid leukemia during first complete remission: a clinical perspective.
Allogeneic hematopoietic cell transplantation (HCT) is the most potent therapy for preventing relapse of acute myeloid leukemia (AML). Although its efficacy is compromised by a high risk of treatment-related morbidity and mortality, an accumulating body of evidence has led to the general recommendation favoring allogeneic HCT from a matched sibling donor during first complete remission (CR1) fo...
متن کاملBusulfan and melphalan as conditioning regimen for allogeneic hematopoietic stem cell transplantation in acute myeloid leukemia in first complete remission
BACKGROUND Allogeneic hematopoietic stem cell transplantation with HLA-identical donors has been established for the treatment of acute myeloid leukemia patients for over 30 years with a cure rate of 50% to 60%. OBJECTIVES To analyze the overall survival of patients and identify factors that influence the outcomes of this type of transplant in patients in 1st complete remission who received a...
متن کاملAllogeneic hematopoietic cell transplantation for acute leukemia in first relapse or second remission
BACKGROUND The role of pre-transplant salvage chemotherapy has been controversial in relapsed acute leukemia. METHODS We investigated post-transplant outcomes in 65 patients with acute leukemia treated with allogeneic hematopoietic cell transplantation (HCT) during first relapse or second remission. RESULTS The 5-year cumulative incidence of relapse (CIR) was 52.3%. Multivariate analysis fo...
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ژورنال
عنوان ژورنال: Haematologica
سال: 2015
ISSN: 0390-6078,1592-8721
DOI: 10.3324/haematol.2014.118570